BACK TO HOME
Important Safety Information
EMAIL THIS PAGE
GoutSmart

Understanding What Causes Gout

For many people, gout means one thing: PAIN. Some people with gout describe the pain of an attack as so excruciating that they cringe at the thought of putting a sheet over their foot at night, never mind putting on their shoes and walking around during the day. But many people don't know what actually causes this pain in the first place. If you have gout, it's a chronic form of arthritis caused by a buildup of uric acid in your blood.

The medical name for this uric acid buildup is hyperuricemia ('hi-per-'yuri-'seem-ee-uh); hyperuricemia is the root cause of gout. If you have gout, high uric acid can lead to more attacks.

Gout's Root Cause: Elevated Uric Acid Levels

Hyperuricemia: High Uric Acid Levels Come From Purines Uric acid comes from substances called purines. As much as two thirds of uric acid is made naturally by your body. The remaining third comes from some of the things you eat and drink.
Learn more about diet and purines


Most people are able to rid their bodies of uric acid. But, if your body produces too much uric acid and/or has a difficult time getting rid of uric acid, it builds up in your blood to higher-than-healthy levels. If you have gout, high uric acid can lead to more attacks.


While limiting alcohol and certain foods is important, diet changes alone will not typically be enough to get rid of the buildup of uric acid to help reduce gout attacks.

Lowering Uric Acid Levels Can Help You Manage Gout

If you have gout, high uric acid buildup can lead to more attacks. To help reduce gout attacks, lower your uric acid to a healthy level.
Learn about treatment for gout patients that helps lower uric acid levels

Uric Acid Crystals Cause Joint Pain

Over time, excess uric acid can form crystals that deposit in the joints, causing inflammation. This inflammation leads to the swelling and severe pain, tenderness, redness, and heat you know all too well as a gout attack.

What Triggers Gout Attacks?

It is hard to say exactly what triggers a gout attack. They sometimes occur for no apparent reason…other times, something may seem to trigger the attack. Gout attacks may be triggered by alcohol, certain medicines, another illness, stressful events, or other factors.

Other known gout triggers include:

  • Joint injury
  • Eating too much of certain foods
  • Infection
  • Surgery
  • Crash diets
  • Rapid lowering of uric acid levels with uric acid-lowering medicines
  • Some cancer treatments

Still Not Convinced?

More on why lowering uric acid levels makes a difference for adults with gout

Once the pain of your attack passes, you probably want to forget about it as soon as possible…but that's not the best idea. Once you have a gout attack, you may not have another attack for months or even years. But very few people (only 7%) just have a single gout attack; most people experience a second attack within 6 months to 2 years of the first. Over time, gout attacks can become more frequent and severe, last longer, and affect one or more joints. That's why keeping your uric acid level low (less than 6 mg/dL) is the goal for long-term management of gout.


ULORIC at Work

ULORIC is a prescription medication for adults with gout that is used to lower uric acid levels, the root cause of gout.

See how it works


ULORIC & a Healthy Diet
Help Control Uric Acid

A healthy lifestyle and diet are good for you. But, for many people with gout, it may not be enough to keep uric acid in a healthy range (less than 6 mg/dL). ULORIC and a healthy diet can work together to help control uric acid.

Learn how


Get to Know More
About ULORIC

ULORIC is a prescription medicine used to lower blood uric acid levels in adults with gout. ULORIC is not for the treatment of high uric acid without a history of gout.

Learn more


Use of ULORIC

ULORIC is a prescription medicine used to lower blood uric acid levels in adults with gout. ULORIC is not for the treatment of high uric acid without a history of gout.

Individual results may vary.

Important Safety Information

Do not take ULORIC if you are taking Azathioprine, Mercaptopurine, or Theophylline.

For some people, gout may flare up when starting certain gout medicines, including ULORIC. If you have a flare while taking ULORIC, do not stop taking your medicine. Your healthcare provider may give you other medicines to help prevent your gout flares.

A small number of heart attacks, strokes, and heart-related deaths were seen in clinical studies. It is not certain that ULORIC caused these events.

Your healthcare professional may do blood tests to check your liver function while you are taking ULORIC.

Tell your healthcare professional about liver or kidney problems or a history of heart disease or stroke.

The most common side effects of ULORIC are liver problems, nausea, gout flares, joint pain, and rash.

Please see the complete Prescribing Information and talk to your healthcare professional.

You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

ULORIC® is a registered trademark of Teijin Pharma Limited and used under license by Takeda Pharmaceuticals America, Inc.
All other trademark names are the property of their respective owners.
©2010 Takeda Pharmaceuticals North America, Inc.
This site is intended for use by US residents only.
TXF-00690 05/10