Why Uloric in the treatment of gout?

ULORIC is a treatment option that helps patients stand up to gout by lowering uric acid levels. For the treatment of gout in most people, the goal is to get uric acid levels below 6 mg/dL, which can help reduce future attacks.*

6

Below six
is the target

Lowering uric acid levels, the root cause of gout, below 6 mg/dL is the target

  • Uloric was shown to be effective in lowering uric acid to healthy levels (less than 6 mg/dL).
  • The safety profile of Uloric has been evaluated in more than 4000 patients, in some for more than five years.
  • The safety profile of Uloric has been evaluated in gout patients that were dealing with a kidney problem called chronic kidney disease (CKD). The dose of Uloric is limited to 40 mg once daily in patients with severe kidney problems. If you have kidney problems, talk to your healthcare professional.

*Individual results may vary.

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Comparing Uloric
and Allopurinol

In clinical studies, more patients achieved uric acid levels
below 6 mg/dL with ULORIC 80 mg than with allopurinol.

  • 7 out of 10 gout patients taking ULORIC 80 mg reached a target uric acid level, less than 6 mg/dL
  • As many patients on ULORIC 40 mg reached a healthy uric acid level as those on allopurinol

ULORIC offers some key differences in patients with mild to moderate kidney problems

  • More patients with mild to moderate kidney problems reached a healthy uric acid level (less than 6 mg/dL) while taking ULORIC compared with allopurinol
  • Unlike patients using allopurinol, patients with mild to moderate kidney problems do not have to change doses with ULORIC. The dose of ULORIC is limited to 40 mg once daily in patients with severe kidney problems.

ULORIC is not indicated to treat chronic kidney disease

If you have kidney problems, ask your healthcare professional about the differences between medicines used to lower uric acid levels.

Chart showing how ULORIC compares with allopurinol in lowering uric acid levels Chart showing how ULORIC compares with allopurinol in lowering uric acid levels

Based on results combined across three phase 3 studies ranging from 6-12 months; ULORIC 40 mg was only included in one of the studies, and ULORIC 80 mg and allopurinol were included in each of the studies.

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Discuss Gout with Your Doctor

This downloadable Doctor Discussion Guide can help get the conversation going.

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Important Safety Information for Uloric (febuxostat)

Do not take Uloric if you are taking azathioprine or mercaptopurine.

Uloric may cause serious side effects, including:

Gout Flares. Gout flares can happen when you first start taking Uloric. Your healthcare provider may give you other medicines to help prevent your gout flares.

Heart Problems. People who take Uloric can have serious heart problems including heart attacks, strokes and heart-related deaths. It is not known that Uloric caused these problems. Call your healthcare provider right away or get emergency medical help if you have any of the following symptoms: chest pain, shortness of breath, dizziness, numbness or weakness on one side of your body, trouble talking or headache.

Liver Problems. Liver problems can happen in people who take Uloric. Your healthcare provider may do blood tests to check how well your liver is working before and during your treatment with Uloric.

Severe Skin and Allergic Reactions. Serious skin and allergic reactions that may affect different parts of the body such as your liver, kidneys, heart or lungs, can happen in people who take Uloric. Call your healthcare provider right away or get emergency medical help if you have any of the following symptoms: rash, red and painful skin, severe skin blisters, peeling skin, sores around the lips, eyes or mouth, swollen face, lips, mouth, tongue or throat, or flu-like symptoms.

The most common side effects of Uloric include liver problems, nausea, gout flares, joint pain, and rash. Tell your healthcare provider if you have any side effect that bothers you, or that does not go away.

Use of Uloric

Uloric is a prescription medicine used to lower blood uric acid levels in adults with gout. Uloric is not for the treatment of high uric acid without a history of gout.

Individual results may vary.

Please see the complete Prescribing Information and talk to your healthcare professional.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Important Safety Information for Uloric (febuxostat)

Do not take Uloric if you are taking azathioprine or mercaptopurine.

Uloric may cause serious side effects, including:

Gout Flares. Gout flares can happen when you first start taking Uloric. Your healthcare provider may give you other medicines to help prevent your gout flares.

Heart Problems. People who take Uloric can have serious heart problems including heart attacks, strokes and heart-related deaths. It is not known that Uloric caused these problems. Call your healthcare provider right away or get emergency medical help if you have any of the following symptoms: chest pain, shortness of breath, dizziness, numbness or weakness on one side of your body, trouble talking or headache.

Liver Problems. Liver problems can happen in people who take Uloric. Your healthcare provider may do blood tests to check how well your liver is working before and during your treatment with Uloric.

Severe Skin and Allergic Reactions. Serious skin and allergic reactions that may affect different parts of the body such as your liver, kidneys, heart or lungs, can happen in people who take Uloric. Call your healthcare provider right away or get emergency medical help if you have any of the following symptoms: rash, red and painful skin, severe skin blisters, peeling skin, sores around the lips, eyes or mouth, swollen face, lips, mouth, tongue or throat, or flu-like symptoms.

The most common side effects of Uloric include liver problems, nausea, gout flares, joint pain, and rash. Tell your healthcare provider if you have any side effect that bothers you, or that does not go away.

Use of Uloric

Uloric is a prescription medicine used to lower blood uric acid levels in adults with gout. Uloric is not for the treatment of high uric acid without a history of gout.

Individual results may vary.

Please see the complete Prescribing Information and talk to your healthcare professional.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.