GOUT RISK FACTORS

Gout is caused by a high level of uric acid in the body. Certain factors increase your risk for gout. The more of them you have, the more likely you are to develop this condition.

Risk factors for gout include:

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    Sex and age

    Men are more likely to develop gout earlier than women—usually between the ages of 40 and 50. However, after menopause, women's uric acid levels approach those of men.
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    Obesity

    Being overweight or obese may increase your risk of developing gout. Obesity has been shown to increase uric acid production.
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    A family history

    If you think you may have inherited your gout, you could be right. How much is due to family history is often hard to know exactly because of other factors, such as environment and dietary habits. Remember though, even if your gout is inherited, the goal is to lower your uric acid to a healthy level (less than 6 mg/dL).

    In two large studies carried out in England and the United States, researchers found that about 40% of participants with gout had a family history of gout.

    If you have a family history of gout, be sure to talk to your doctor.
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    Specific medications

    If you have undergone an organ transplant and are taking anti-rejection drugs, you are at risk for an increase in uric acid levels. If you are using thiazide diuretics to treat hypertension, you are at risk for an increase in uric acid levels.
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    Diet and alcohol

    The breakdown of alcohol in your body is thought to increase uric acid production. Consuming certain types of alcohol may be associated with an increased risk of gout and recurring attacks.

    High purine foods include:

    • beef, game meats, liver and sweetbreads
    • seafood: herring, mackerel, anchovies, sardines, scallops
    • mushrooms, dried beans, peas.


    Diet changes alone may not be enough to lower uric acid levels. In fact, a low-purine diet has been shown to reduce uric acid levels by about 1 mg/dL.

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IMPORTANT SAFETY INFORMATION FOR ULORIC

Do not take ULORIC if you are taking azathioprine or mercaptopurine.

ULORIC may cause serious side effects, including:

Gout Flares. Gout flares can happen when you first start taking ULORIC. Your healthcare provider may give you other medicines to help prevent your gout flares.

Heart Problems. People who take ULORIC can have serious heart problems including heart attacks, strokes and heart-related deaths. It is not known that ULORIC caused these problems. Call your healthcare provider right away or get emergency medical help if you have any of the following symptoms: chest pain, shortness of breath, dizziness, numbness or weakness on one side of your body, trouble talking or headache.

Liver Problems. Liver problems can happen in people who take ULORIC. Your healthcare provider may do blood tests to check how well your liver is working before and during your treatment with ULORIC.

Severe Skin and Allergic Reactions. Serious skin and allergic reactions that may affect different parts of the body such as your liver, kidneys, heart or lungs, can happen in people who take ULORIC. Call your healthcare provider right away or get emergency medical help if you have any of the following symptoms: rash, red and painful skin, severe skin blisters, peeling skin, sores around the lips, eyes or mouth, swollen face, lips, mouth, tongue or throat, or flu-like symptoms.

The most common side effects of ULORIC include liver problems, nausea, gout flares, joint pain, and rash. Tell your healthcare provider if you have any side effect that bothers you, or that does not go away.

USE OF ULORIC

ULORIC is a prescription medicine used to lower blood uric acid levels in adults with gout. ULORIC is not for the treatment of high uric acid without a history of gout.

Individual results may vary.

Please see the complete Prescribing Information and talk to your healthcare professional.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.

Important Safety Information for ULORIC (FEBUXOSTAT)

Do not take ULORIC if you are taking azathioprine or mercaptopurine.

ULORIC may cause serious side effects, including:

Gout Flares. Gout flares can happen when you first start taking ULORIC. Your healthcare provider may give you other medicines to help prevent your gout flares.

Heart Problems. People who take ULORIC can have serious heart problems including heart attacks, strokes and heart-related deaths. It is not known that ULORIC caused these problems. Call your healthcare provider right away or get emergency medical help if you have any of the following symptoms: chest pain, shortness of breath, dizziness, numbness or weakness on one side of your body, trouble talking or headache.

Liver Problems. Liver problems can happen in people who take ULORIC. Your healthcare provider may do blood tests to check how well your liver is working before and during your treatment with ULORIC.

Severe Skin and Allergic Reactions. Serious skin and allergic reactions that may affect different parts of the body such as your liver, kidneys, heart or lungs, can happen in people who take ULORIC. Call your healthcare provider right away or get emergency medical help if you have any of the following symptoms: rash, red and painful skin, severe skin blisters, peeling skin, sores around the lips, eyes or mouth, swollen face, lips, mouth, tongue or throat, or flu-like symptoms.

The most common side effects of ULORIC include liver problems, nausea, gout flares, joint pain, and rash. Tell your healthcare provider if you have any side effect that bothers you, or that does not go away.

USE OF ULORIC

ULORIC is a prescription medicine used to lower blood uric acid levels in adults with gout. ULORIC is not for the treatment of high uric acid without a history of gout.

Individual results may vary.

Please see the complete Prescribing Information and talk to your healthcare professional.

You are encouraged to report negative side effects of prescription drugs to the FDA.
Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.